Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

948
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
948
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

4.1K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
4.1K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

880
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
880
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

625
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
625
Hand hygiene01:23

Hand hygiene

5.6K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
5.6K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.2K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the predictability of progression-free survival in ovarian cancer from NanoString gene expression data.

bioRxiv : the preprint server for biology·2026
Same author

Cognability across adulthood: A qualitative investigation of neighborhoods and cognitive health behaviors.

Social science & medicine (1982)·2026
Same author

A Risk-Structured Model of the Influence of Mental Health on Opioid Addiction.

Bulletin of mathematical biology·2025
Same author

Variation in Avian Predation Pressure as a Driver for the Diversification of Periodical Cicada Broods.

The American naturalist·2024
Same author

Optimal spatial evaluation of a pro rata vaccine distribution rule for COVID-19.

Scientific reports·2023
Same author

Cumulative cultural evolution and mechanisms for cultural selection in wild bird songs.

Nature communications·2022

Related Experiment Video

Updated: Jan 21, 2026

Principles of Rodent Surgery for the New Surgeon
10:29

Principles of Rodent Surgery for the New Surgeon

Published on: January 6, 2011

117.0K

Modeling opioid use disorder in hand surgery patients.

Grace Bowman1, Julie C Blackwood2, Kathryn J Montovan3

  • 1Department of Ecology and Evolutionary Biology, University of Colorado Boulder, 1236 Broadway St, Boulder, CO 80302, USA.

Mathematical Medicine and Biology : a Journal of the IMA
|January 20, 2026
PubMed
Summary

Prescription opioid misuse is a major public health issue, particularly after hand surgery. This study modeled how prescription numbers impact opioid use disorder (OUD) risk, revealing complex relationships between prescribing patterns and addiction.

Keywords:
compartmental modelopioid use disorderprescription opioids

More Related Videos

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training
09:15

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training

Published on: February 10, 2022

4.1K
A Murine Model of Hemodialysis Access-Related Hand Dysfunction
08:39

A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Published on: May 31, 2022

2.0K

Related Experiment Videos

Last Updated: Jan 21, 2026

Principles of Rodent Surgery for the New Surgeon
10:29

Principles of Rodent Surgery for the New Surgeon

Published on: January 6, 2011

117.0K
Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training
09:15

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training

Published on: February 10, 2022

4.1K
A Murine Model of Hemodialysis Access-Related Hand Dysfunction
08:39

A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Published on: May 31, 2022

2.0K

Area of Science:

  • Public Health
  • Epidemiology
  • Addiction Medicine

Background:

  • Prescription opioids are a leading cause of misuse and overdose deaths, with nearly 300,000 deaths from 1999-2022.
  • Hand surgery patients exhibit high rates of prolonged post-operative opioid use and opioid use disorder (OUD).

Purpose of the Study:

  • To develop and utilize a compartmental model to understand the progression from opioid exposure to OUD in hand surgery patients.
  • To investigate the relationship between the quantity of opioid prescriptions and the risk of opioid abuse in this population.

Main Methods:

  • A compartmental model was constructed to simulate opioid exposure and OUD development.
  • The model was parameterized using empirical patient data from hand surgery populations.
  • The model was used to explore the functional relationship between prescription numbers and opioid abuse risk.

Main Results:

  • The study identified a non-linear relationship between the number of opioid prescriptions and the risk of developing opioid abuse.
  • The specific risk associated with a given number of prescriptions varies based on the assumed opioid addiction risk curve.
  • Findings highlight the nuanced impact of prescription quantity on OUD development.

Conclusions:

  • Prescription patterns significantly influence the development of opioid use disorder in hand surgery patients.
  • Understanding these relationships is crucial for developing targeted interventions to mitigate OUD risk.
  • The study advances knowledge on how prescription quantity affects OUD trajectories.