Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Frequency of Spring-Mass System01:17

Frequency of Spring-Mass System

7.4K
One interesting characteristic of the simple harmonic motion (SHM) of an object attached to a spring is that the angular frequency, and the period and frequency of the motion, depend only on the mass and the force constant of the spring, and not on other factors such as the amplitude of the motion or initial conditions. We can use the equations of motion and Newton's second law to find the angular frequency, frequency, and period.
Consider a block on a spring on a frictionless surface. There...
7.4K
Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

Nonlinear Pharmacokinetics: Causes of Nonlinearity

712
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
712
Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview01:25

Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview

338
Drug administration can occur through various routes, each of which may result in a different process of elimination. This process is often mixed with nonlinear and linear processes. It's important to understand that a single drug can be metabolized into different metabolites through parallel processes.
For instance, consider the metabolism of sodium salicylate. This compound is metabolized into two distinct substances: a glucuronide and a glycine conjugate. The rate of conjugation depends...
338
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

295
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
295
Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

1.1K
Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
1.1K
Physical and Chemical Properties of Matter02:57

Physical and Chemical Properties of Matter

165.4K
The characteristics that enable us to distinguish one substance from another are called properties.
165.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interfacial Growth of 420 nm Ultrathin and Dense MOFs for Composite Electrolyte to Reduce Li<sup>+</sup> Conduction Resistance and Inhibit Lithium Dendrite.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Letter to the Editor: Effect of Acupressure on Anxiety, Embarrassment, and Procedural Fear in Patients Undergoing Urodynamic Testing: Randomized Controlled Study.

Neurourology and urodynamics·2026
Same author

A grading system based on multiparametric MRI-predicted tumor perfusion, invasiveness and texture (GOLDS-PIT) for surgical difficulty assessment in pituitary macroadenomas: A prospective single-centre cohort study.

World neurosurgery·2026
Same author

A Restricted Two-Stage Multi-Locus Multi-Allele Genome-Wide Association Study Reveals Genomic Loci and Candidate Genes Controlling Plant-Height-Related Traits in Soybean Under Normal and Shade Conditions.

International journal of molecular sciences·2026
Same author

Reliability of surface topography for scoliosis assessment: a systematic review and meta-analysis based on the COSMIN guideline.

BMC musculoskeletal disorders·2026
Same author

A mechanism of target mRNA selection and activity regulation in meiosis-related RBM46-MEIOC-YTHDC2 complex.

iScience·2026

Related Experiment Video

Updated: Jan 21, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

9.2K

A multi-directional mass-spring-damper model for simulating nonlinear breast dynamics during physical activity.

Ruixin Liang1, Hongyi Xia1, Jingyi Ma1

  • 1School of Fashion and Textiles, The Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region (SAR).

Computer Methods in Biomechanics and Biomedical Engineering
|January 20, 2026
PubMed
Summary
This summary is machine-generated.

A new 3D nonlinear mass-spring-damper (MSD) model accurately simulates breast biomechanics during activities like running. This advanced model offers a practical tool for research and clinical applications.

Keywords:
Breast simulationbiomechanicsmass-spring-damper model

More Related Videos

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package
06:37

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package

Published on: September 17, 2021

5.0K
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.2K

Related Experiment Videos

Last Updated: Jan 21, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

9.2K
Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package
06:37

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package

Published on: September 17, 2021

5.0K
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.2K

Area of Science:

  • Biomechanics
  • Computational modeling
  • Human physiology

Background:

  • Breast biomechanics during dynamic activities present complex nonlinear dynamics.
  • Conventional 1D models fail to capture these intricate movements accurately.
  • A need exists for sophisticated models to understand breast motion.

Purpose of the Study:

  • To develop and validate a 3D nonlinear mass-spring-damper (MSD) model for simulating breast dynamics.
  • To improve the accuracy of breast biomechanical simulations.
  • To provide a practical tool for research and clinical applications.

Main Methods:

  • Developed a 3D nonlinear MSD model with 16 springs, 16 dampers, and 9 mass blocks.
  • Integrated tissue heterogeneity and multi-directional displacement replication.
  • Optimized model parameters via iterative calibration against 5 km/h running motion capture data.
  • Validated the model using independent 10 km/h running data.

Main Results:

  • Simulated displacement trajectories closely matched experimental data.
  • Achieved mean relative errors below 3% across all three directions (X, Y, Z).
  • Demonstrated the model's ability to reliably simulate complex breast biomechanics.

Conclusions:

  • A computationally efficient 3D MSD model, enhanced by data-driven parameter optimization, accurately simulates breast biomechanics.
  • The model offers a novel and practical approach for breast biomechanical research.
  • Potential utility in clinical settings and biomechanical engineering is highlighted.