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Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model
Sua Lee1, Sheng Cui2, Xianying Fang2
1Division of Nephrology, Department of Internal Medicine, Daejeon Eulji Medical Center, School of Medicine, Eulji University, Daejeon, Korea.
Journal of Korean Medical Science
|January 20, 2026
Summary
High-dose Chaga mushroom consumption in rats led to kidney damage, indicated by crystal deposition and impaired renal function. This suggests a potential risk associated with excessive intake of this oxalate-rich mushroom.
Area of Science:
- Nephrology
- Toxicology
- Mycology
Background:
- Kidney damage can stem from endogenous oxalate overproduction or high dietary intake.
- Chaga mushroom is known for its high oxalate content, raising concerns about its potential nephrotoxicity.
Purpose of the Study:
- To investigate the potential kidney injury induced by oxalate-rich Chaga mushroom consumption.
- To evaluate the effects of varying doses of Chaga mushroom on renal function and kidney tissue.
Main Methods:
- Wistar rats were administered Chaga mushroom powder at standard and high doses (1,281.6 mg/kg and 3,844.8 mg/kg, respectively) or a control diet.
- Chronic kidney injury was assessed through renal function tests, histopathology, and evaluation of oxidative stress and apoptosis markers.
Main Results:
- High-dose Chaga mushroom intake significantly reduced body weight and increased urinary protein excretion.
- Histopathology revealed oxalate crystal deposition and tubular injury in high-dose rats.
- Elevated markers of oxidative stress, inflammation (CD68/SR-D1), and apoptosis (Bax, TUNEL) were observed in the high-dose group.
Conclusions:
- Excessive consumption of Chaga mushroom may induce kidney damage.
- The high oxalate content in Chaga mushrooms is implicated as the causative factor for observed nephrotoxicity.
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