Unusual Cytology Features of A DICER1-Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration
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Updated: Jan 21, 2026

Detection of Extravascular Trypanosoma Parasites by Fine Needle Aspiration
Published on: August 7, 2019
Wenli Dai1,2, Eduardo V Zambrano3,4,5, Sabri Yilmaz2,6
1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Abstract:
DICER1-mutated thyroid lesions can range from indolent to aggressive neoplasms. Infarction has been recently described as a histologic feature of DICER1-mutated thyroid nodules. In this case report, we presented a DICER1-mutated nodule which presented predominantly with debris in the fine needle aspiration (FNA) specimen and was confirmed on surgical resection to be a near total infarcted nodule. To the best of our knowledge, this is the first cytopathology report of a DICER1-mutated thyroid lesion presenting as an infarcted nodule. Awareness of the features described herein may help prevent both overdiagnosis and underdiagnosis in the evaluation of thyroid nodules via FNA.
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