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Overview
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Efficacy And Safety Of Aerosol Inhalation Of Recombinant Human Interferon-α2b Injection In Children Hospitalized With Human Adenovirus Pneumonia: A Prospective, Multicenter, Randomized, Controlled Trial In China

Efficacy and safety of aerosol inhalation of recombinant human interferon-α2b injection in children hospitalized with human adenovirus pneumonia: a prospective, multicenter, randomized, controlled trial in China

Hai-Feng Liu1,2, Xue-Zu Zhang3, Pei-Yan Li4

  • 1Department of Pulmonary and Critical Care Medicine, Yunnan Medical Center for Pediatric Diseases, Kunming Children's Hospital, Children's Hospital Affiliated to Kunming Medical University, Kunming, China.

International Journal of Surgery (London, England)
|January 20, 2026

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View abstract on PubMed

Summary
This summary is machine-generated.

Aerosolized recombinant human interferon-alfa2b (IFN-α2b) effectively treated adenovirus pneumonia in children. This safe antiviral therapy improved clinical outcomes and viral clearance with no significant adverse events.

Area of Science:

  • Pediatric infectious diseases
  • Respiratory viral infections
Keywords:
aerosol inhalationchildrenhuman adenovirusinterferon-α2b

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  • Interferon-based therapies

    • Background:

    • Human adenovirus (HAdV) pneumonia poses a severe global threat to children's health.
    • Limited effective and safe antiviral treatments are available for HAdV infections.
    • Investigating novel therapeutic strategies is crucial for managing pediatric HAdV pneumonia.

    Purpose of the Study:

    • To evaluate the efficacy and safety of aerosol inhalation of recombinant human interferon-α2b (IFN-α2b) in children hospitalized with HAdV pneumonia.
    • To compare IFN-α2b treatment with standard supportive care.
    • To assess viral DNA negative conversion and overall clinical effectiveness.

    Main Methods:

    • A randomized controlled trial involving children aged ≤5 years with HAdV pneumonia.
    • Treatment groups received either aerosolized IFN-α2b or normal saline, alongside supportive care for 7 days.
    • Outcomes included viral DNA negative conversion, symptom resolution, inflammatory markers, and safety assessments.

    Main Results:

    • The IFN-α2b group showed significantly higher viral DNA negative conversion rates (71.4% vs. 52.9%) and overall effectiveness (97.1% vs. 85.7%).
    • Patients receiving IFN-α2b experienced shorter symptom disappearance times and improved clinical cure proportions (70.0% vs. 48.6%).
    • No significant differences in safety parameters, including vital signs and liver/kidney function, were observed between groups.

    Conclusions:

    • Aerosol inhalation of recombinant human IFN-α2b is a safe and effective treatment for pediatric HAdV pneumonia.
    • IFN-α2b demonstrates significant therapeutic benefits in improving clinical outcomes and viral clearance.
    • This approach offers a promising antiviral strategy for managing HAdV pneumonia in children.
    pneumonia
    randomized controlled trial