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SCN5A R814W-Associated Multifocal Ventricular Ectopy and Dilated Cardiomyopathy: A Treatable Channelopathy

Marta Catarina Bernardo1, Isabel Martins Moreira1, José Pedro Guimarães1

  • 1Cardiology Department, Local Health Unit of Trás-os-Montes e Alto-Douro, Vila Real, Portugal.

Journal of Cardiovascular Electrophysiology
|January 20, 2026
PubMed
Abstract

Insights

Multifocal ectopic Purkinje-related premature contractions (MEPPC), a syndrome linked to SCN5A variants, can cause heart failure. This case highlights quinidine

Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Multifocal ectopic Purkinje-related premature contractions (MEPPC) is a genetic syndrome.
  • It is characterized by SCN5A gain-of-function variants, multifocal ventricular ectopy, and dilated cardiomyopathy (DCM).

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