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Updated: Jan 22, 2026

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
Published on: December 8, 2014
miR-26b-5p responds to aerobic exercise intervention for concussion recovery in adolescent athletes: a pilot trial
Haley Chizuk1, Jeffrey C Miecznikowski2, Alex Rawlings1
1UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York.
Background:
Guidelines for sport-related concussion (SRC) management recommend aerobic exercise treatment. Salivary microRNAs (miRNAs) associate with exercise and concussion; therefore, we investigated their expression in adolescents with SRC during prescribed exercise.
Methods:
Before and after intervention, athletes with SRC (n = 32, 15.78 ± 1.5 y/o, 66% male, 5.26 ± 3.56 days from injury) and controls (n = 28, 15.96 ± 1.7 y/o, 68% male) provided saliva samples and completed clinical exams. High (5 days/week, 30 min) or low (3 days/week, 20 min) volumes of aerobic exercise were assigned. RT-qPCRs were performed to assess 13 pre-selected miRNAs.
Results:
miRNAs 1246, 944, 151a-3p, and 26b-5p were reduced (p = 0.0002, 0.0024, 0.0015, 0.0002, CI mean difference: [-4.55, -1.54] [-4.58, -1.08] [-4.77, -1.24] [-5.64, -1.92], respectively) compared to controls. The expression of 182-5p, 532-3p, and 26b-5p increased with exercise volume in concussed participants (p = 0.0035, 0.0035, 0.0020, CI for exercise coefficient: [0.000100, 0.000396] [0.000060, 0.000237] [0.000107, 0.000373], respectively), but not in controls.
Conclusion:
miRNAs 1246, 944, and 151a-3p may be concussion biomarkers unaffected by aerobic exercise. miR-26b-5p, associated with concussion and exercise volume, may be a useful biomarker to monitor adherence to exercise prescriptions for SRC recovery.
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10:31A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
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05:48Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
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