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Occupational therapy for multiple sclerosis.

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|January 20, 2026
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Summary
This summary is machine-generated.

Occupational therapy (OT) may enhance daily functioning and mental health-related quality of life for individuals with multiple sclerosis (MS). However, evidence for long-term effects and physical quality of life remains uncertain, with no reported adverse effects.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Occupational Therapy

Background:

  • Multiple sclerosis (MS) impacts daily activities, with occupational therapy (OT) recognized as a key support.
  • The precise benefits of OT for individuals with MS require further clarification.

Purpose of the Study:

  • To systematically assess the benefits and harms of OT interventions for improving daily functioning, participation, and quality of life in people with MS.
  • To evaluate outcomes at post-intervention, medium-term, and long-term follow-up points.

Main Methods:

  • A comprehensive search of seven electronic databases, grey literature, and trial registers was conducted up to November 2024.
  • Included were randomized and non-randomized controlled trials comparing OT for adults with MS against no intervention, usual care, or active control.
  • Meta-analysis (random-effects model) and narrative synthesis were employed, with GRADE used to assess evidence certainty.

Main Results:

  • OT interventions may offer a small to moderate benefit in daily functioning post-intervention, with potential medium-term benefits compared to usual care.
  • A small benefit in mental health-related quality of life (HR-QoL) was observed post-intervention and medium-term compared to active control.
  • Evidence regarding long-term effects, physical HR-QoL, participation, and adverse effects is limited or very uncertain.

Conclusions:

  • Occupational therapy shows potential for improving daily functioning and mental HR-QoL in individuals with MS, particularly in the short to medium term.
  • The evidence base for long-term outcomes and physical HR-QoL is currently limited and requires cautious interpretation.
  • Future high-quality studies are necessary to establish definitive conclusions on the efficacy of OT for MS management.