Related Experiment Video
Updated: Jan 22, 2026
10:09
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
Published on: May 11, 2015
10.0K
Lifespan Pancreas Morphology for Control Versus Type 2 Diabetes Using AI on Largescale Clinical Imaging
Lucas W Remedios1, Chloe Cho2, Trent M Schwartz3
1Department of Computer Science, Vanderbilt University, Nashville, USA.
Clinical Anatomy (New York, N.Y.)
|January 20, 2026
Summary
Pancreas size and shape change with age. Type 2 diabetes is linked to significant differences in these aging trends, with the pancreas appearing smaller in affected individuals.
Area of Science:
- Medical Imaging
- Radiology
- Endocrinology
Background:
- Understanding normal pancreas morphology across the lifespan is crucial for identifying pathological changes.
- Aging affects organ size and shape, necessitating age-specific reference data.
- Deviations in pancreas morphology may indicate conditions like type 2 diabetes.
Purpose of the Study:
- To identify reliable imaging modalities for artificial intelligence (AI)-based pancreas measurement.
- To establish normative morphological aging trends of the pancreas.
- To detect potential deviations in pancreas morphology associated with type 2 diabetes.
Main Methods:
- Analysis of 2533 patients' abdominal computed tomography (CT) or magnetic resonance imaging (MRI) scans.
- AI-based segmentation and extraction of 13 morphological pancreas features.
- Generative additive models for location, scale, and shape (GAMLSS) regression to model aging trends and compare diabetic vs. non-diabetic cohorts.
Main Results:
- Computed tomography (CT) was selected as the primary modality due to consistent AI-based measurements.
- Significant differences in aging trends for 10 of 13 morphological features were observed between type 2 diabetes patients and controls (p < 0.05).
- The pancreas was found to be smaller in individuals with type 2 diabetes.
Conclusions:
- Normative lifespan trends for 13 pancreatic morphological measurements were established.
- Pancreas morphology is altered in type 2 diabetes, reinforcing findings of a smaller pancreas.
- The study provides a valuable clinical reference for lifespan pancreas morphology in non-diabetic individuals.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
4.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.4K
01:22Diabetes Mellitus: Overview and Type I Subtype
5.0K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.0K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
414
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
414
01:19Pancreas
2.2K
The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
2.2K
02:13Types of Hormones
83.1K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.1K
01:16Cells and Secretions of the Pancreas
4.5K
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
4.5K