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Published on: May 12, 2018
Neonicotinoid-Induced Neurotoxicity in Developing Brain: A Systematic Review.
Dhanshree Sayangrushi Borkar1, Dnyaneshwari Shivshankar Pande1, Rajesh Singh Yadav1
1School of Forensic Science, National Forensic Sciences University (An Institution of National Importance), Ministry of Home Affairs, Government of India, Bhopal, India.
Neonicotinoid insecticides can harm the developing nervous systems of humans and animals. This review of 35 studies confirms neonicotinoid exposure causes neurotoxic effects and behavioral changes, necessitating further investigation.
Area of Science:
- Environmental Health
- Toxicology
- Neuroscience
Background:
- Environmental contaminants pose significant health risks, particularly developmental neurotoxicity.
- Neonicotinoids, widely used insecticides, are increasingly scrutinized for potential adverse effects on non-target organisms.
- While designed to target insect nicotinic acetylcholine receptors (nAChRs), concerns exist regarding their impact on mammalian nervous systems.
Conclusions:
- Neonicotinoid exposure presents a risk for developmental neurotoxicity in humans and animals.
- Further research is warranted to fully understand the mechanisms and long-term consequences of neonicotinoid exposure on neurological health.
- Investigating neuropathological, neurological, biochemical, and genetic alterations is crucial for risk assessment.
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