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Related Concept Videos

Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

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During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
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Revisionist Views of Adolescent and Adult Cognition01:24

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A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
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In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
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Updated: Jan 22, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
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Reducing self-harm in adolescents: the RISA-IPD comprehensive synopsis.

David Cottrell1, Rebecca Walwyn2, Amanda Farrin2

  • 1Division of Psychological & Social Medicine, Leeds Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, UK.

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|January 20, 2026
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Summary
This summary is machine-generated.

This meta-analysis found no evidence that therapeutic interventions reduce repeat self-harm in adolescents. However, participants with multiple prior self-harm episodes showed improved treatment effects, suggesting potential subgroup benefits.

Keywords:
ADOLESCENTSINTERVENTIONSIPD META-ANALYSISRANDOMISED CONTROLLED TRIALSSELF-HARMSUICIDE ATTEMPTSSYSTEMATIC REVIEW

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Area of Science:

  • Adolescent mental health research
  • Public health interventions
  • Evidence-based practice

Background:

  • Self-harm is a significant public health concern in adolescents, with a lack of evidence for effective interventions.
  • Individual participant data meta-analysis offers a robust method for evaluating therapeutic effects and identifying tailored treatments.

Purpose of the Study:

  • To systematically review and conduct an individual participant data meta-analysis of randomized controlled trials (RCTs) for therapeutic interventions aimed at reducing repeat self-harm in adolescents.
  • To explore the effectiveness of various interventions and identify which treatments are most suitable for specific adolescent subgroups.

Main Methods:

  • Systematic review and individual participant data meta-analysis of RCTs involving adolescents (11-18 years) with a history of self-harm.
  • Inclusion of 26 studies with individual participant data (3448 participants) and aggregate data from 7 additional studies (698 participants).
  • Two-stage random-effects models were used to analyze primary (repeat self-harm at 12 months) and secondary outcomes, with metaregression exploring moderators.

Main Results:

  • No significant evidence was found that any therapeutic intervention, overall or by specific type, was more effective than control in preventing repeat self-harm at 12 months.
  • Participants with multiple prior self-harm episodes demonstrated a significantly improved treatment effect on self-harm repetition between 6-12 months.
  • Modest evidence suggested differential treatment effects based on participant age, gender, self-harm method, and anxiety levels.

Conclusions:

  • Current therapeutic interventions do not demonstrate overall effectiveness in reducing repeat self-harm among adolescents.
  • Future research should focus on adaptive platform trial designs to efficiently identify the most effective interventions for specific adolescent subgroups.
  • Improved data-sharing consent and standardized outcome reporting are crucial for future research in this area.