Innovative multimodal management in an aneurysmal bone cyst of the temporal bone: our experience in a 3-month-old infant and literature review
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View abstract on PubMed
Summary
This summary is machine-generated.Aneurysmal bone cysts (ABCs) in the pediatric temporal bone (TB) are rare. A multimodal approach using embolization and Denosumab facilitated safe resection in the youngest reported case, showing no recurrence.
Area Of Science
- Neurosurgery
- Pediatric Oncology
- Radiology
Background
- Aneurysmal bone cysts (ABCs) are benign, locally aggressive osteolytic lesions.
- Cranial involvement, particularly in the temporal bone (TB), is uncommon in pediatric patients.
- TB-ABCs pose diagnostic and management challenges due to their behavior and proximity to critical neurovascular structures.
Purpose Of The Study
- To report the youngest pediatric case of primary temporal bone aneurysmal bone cyst (TB-ABC).
- To describe a novel multimodal treatment strategy for pediatric TB-ABC.
- To review the literature on pediatric TB-ABCs.
Main Methods
- A case of a 3-month-old infant with primary TB-ABC was managed with preoperative embolization and Denosumab.
- A systematic literature review of pediatric TB-ABCs treated surgically was conducted.
- The multimodal strategy aimed to reduce lesion volume and facilitate surgical resection.
Main Results
- The literature review identified ten pediatric TB-ABCs; four had preoperative embolization, none had adjuvant medical therapy.
- The infant patient treated with embolization and Denosumab showed significant lesion volume reduction.
- This approach enabled gross total resection, preserving hearing and facial nerve function, with no recurrence at follow-up.
Conclusions
- Pediatric TB-ABCs are rare and dangerous lesions requiring specialized care.
- Preoperative embolization and targeted medical therapy (like Denosumab) can aid resection.
- A multidisciplinary team approach is crucial for optimal outcomes in managing pediatric TB-ABCs.
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