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Magnetically-guided, stimuli-responsive microdevices for endovascular therapy.

Sanjay Manoharan1, Vivek Subramanian2

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Biomedical Microdevices
|January 20, 2026
PubMed
Summary

This study presents a wireless endovascular microdevice for aneurysm treatment, using magnetic guidance and near-infrared light for remote deployment. This novel platform offers improved access to difficult anatomies, enhancing therapeutic options.

Keywords:
AneurysmEndovascular devicesFlow disruptionMagnetic actuationMicrorobotsStimuli responsive materials

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Area of Science:

  • Biomedical Engineering
  • Medical Devices
  • Materials Science

Background:

  • Catheter-based systems limit endovascular treatment access in complex vascular anatomies.
  • A need exists for advanced, minimally invasive therapeutic strategies for aneurysm repair.

Purpose of the Study:

  • To develop and validate a tetherless microdevice platform for wireless aneurysm therapy.
  • To demonstrate magnetic guidance and near-infrared (NIR) triggered deployment of endovascular devices.
  • To assess the efficacy of the platform in reducing intra-aneurysmal flow.

Main Methods:

  • A microdevice platform combining magnetic guidance and NIR-triggered shape-memory polymer (SMP) deployment was engineered.
  • Two device architectures (flow disruptor, occluder) were designed and tested in vascular phantoms.
  • Navigation was modeled using a flow-responsive, magnetically modulated stick-slip (F-MMSS) framework.
  • Magnetic steering, NIR deployment, and hemodynamic effects were experimentally evaluated.

Main Results:

  • Successful wireless navigation and remote deployment of microdevices were achieved in realistic vascular phantoms.
  • NIR activation enabled non-invasive deployment through ex vivo tissue.
  • Substantial reductions in intra-aneurysmal velocity were confirmed via particle image velocimetry and CFD.
  • PLA-melanin composites demonstrated preliminary biocompatibility and hemocompatibility.

Conclusions:

  • The developed platform provides a proof-of-concept for wireless navigation and remote deployment of endovascular microdevices.
  • This technology offers a promising alternative to catheter-based treatments for aneurysm repair.
  • Further in vivo evaluation is warranted to translate this technology to clinical practice.