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Area of Science:

  • Biomedical imaging
  • Molecular imaging
  • Radiochemistry

Background:

  • Unruptured intracranial aneurysms (IAs) are common, with a need for tools to predict rupture risk.
  • Increased type I collagen turnover is linked to IA wall structural instability.

Purpose of the Study:

  • To develop and test a novel positron emission tomography (PET) tracer, [68Ga]Ga-NODA-GA-PEG1-collagelin, for visualizing immature type I collagen in IAs.
  • To assess the tracer's potential as a marker for IA structural instability and rupture risk.

Main Methods:

  • Synthesis and in vitro/ex vivo validation of [68Ga]Ga-NODA-GA-PEG1-collagelin.
  • Incubation of human IA cryosections with the tracer and quantification via autoradiography.
  • Comparison with polarization microscopy of picrosirius red-stained sections to differentiate collagen maturity.

Main Results:

  • The tracer [68Ga]Ga-NODA-GA-PEG1-collagelin demonstrated specific binding to type I collagen in vitro and ex vivo.
  • In human IAs, the tracer preferentially labeled immature type I collagen.
  • High tracer uptake correlated significantly with immature collagen regions (r=0.40, P=0.002).

Conclusions:

  • [68Ga]Ga-NODA-GA-PEG1-collagelin shows promise as a molecular imaging tool for assessing IA instability.
  • Further animal studies are necessary to evaluate in vivo application in humans.