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Collagen in Fibrotic Diseases.

Andrzej Fertala1

  • 1Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Curtis Building, Philadelphia, PA, USA. andrzej.fertala@jefferson.edu.

Sub-Cellular Biochemistry
|January 20, 2026
PubMed
Summary
This summary is machine-generated.

Fibrillar collagen, primarily collagen I, drives fibrotic disorders by altering tissue mechanics. Targeting collagen-driven stiffness offers a novel therapeutic strategy for fibrosis, distinct from conventional anti-fibrotic agents.

Keywords:
CollagenCollagen fibrilExtracellular matrixFibrosisMatrix stiffnessMechanotransductionMyofibroblastsProcollagenScar

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Tissue Engineering

Background:

  • Fibrotic disorders stem from abnormal collagen accumulation after injury.
  • Collagen I's extracellular architecture, not its basic structure, differs in fibrotic tissues.
  • Excessive collagen I and associated proteins lead to altered tissue mechanics.

Purpose of the Study:

  • To explore fibrillar collagen's role in fibrotic disorder development.
  • To highlight key signaling pathways perpetuating fibrosis.
  • To discuss novel therapeutic strategies targeting mechanotransduction.

Main Methods:

  • Literature review focusing on collagen I biosynthesis and extracellular matrix remodeling.
  • Analysis of mechanotransduction signaling in fibroblasts.
  • Evaluation of therapeutic strategies for fibrosis.

Main Results:

  • Altered collagen I extracellular architecture and physical properties significantly contribute to fibrosis.
  • Mechanotransduction amplifies pro-fibrotic signaling in fibroblasts due to tissue rigidity.
  • Conventional anti-fibrotic agents may impede necessary scarring.

Conclusions:

  • Targeting collagen accumulation-driven scar stiffness offers a novel therapeutic approach.
  • Mechanotherapeutics present a more targeted strategy for anti-fibrotic therapies.
  • Understanding collagen's mechanical role is crucial for developing effective fibrosis treatments.