Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Globular and Fibrous Proteins

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...

Globular and Fibrous Proteins

Globular and Fibrous Proteins

Fibrous Proteins

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...

Structural Joints: Fibrous Joints

Structural Joints: Fibrous Joints

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...

Inflammation

Inflammation

DNA Packaging

DNA Packaging

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The mechanisms of contractile dysfunction following chronic limited platelet activation in (pro)thrombotic conditions.

Thrombosis research·2026

Same author

Contraction of blood clots occurs during hemostasis and hemorrhagic shock to promote closure of lacerations.

Biomaterials·2026

Same author

Early pregravid correction of hemostasis assessed by novel biomarkers improves the outcomes of pregnancies in women with bad obstetric history.

Clinical science (London, England : 1979)·2026

Same author

Response to Letter to the Editor: "Back to the drawing board: Exploring the composition and physical properties of traumatic hemothorax".

The journal of trauma and acute care surgery·2026

Same author

Neutrophil Extracellular Traps Promote Platelet-Driven Contraction of Inflammatory Blood Clots via Local Generation of Endogenous Thrombin and Softening of the Fibrin Network.

Cells·2025

Same author

Shapes and dimensions of blood clots affect the rate and extent of platelet-driven clot contraction and determine the outcomes of thrombosis.

Journal of thrombosis and haemostasis : JTH·2025

Same journal

Future Directions in Biotechnological and Pharmacological Applications of CAIs.

Sub-cellular biochemistry·2026

Same journal

Industrial and Environmental Applications of Carbonic Anhydrases.

Sub-cellular biochemistry·2026

Same journal

Applications of Carbonic Anhydrase Inhibitors in Arthritis, Neuropathic Pain, Acute Mountain Sickness, and Cerebral Ischemia.

Sub-cellular biochemistry·2026

Same journal

Applications of Carbonic Anhydrase Inhibitors in Neurological Disorders, Mechanisms and Therapeutic Potential.

Sub-cellular biochemistry·2026

Same journal

Carbonic Anhydrase Inhibitors in Oncology.

Sub-cellular biochemistry·2026

Same journal

Therapeutic Applications of Carbonic Anhydrase Inhibitors in Ophthalmology.

Sub-cellular biochemistry·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 22, 2026

Molecular Entanglement and Electrospinnability of Biopolymers

Molecular Entanglement and Electrospinnability of Biopolymers

Published on: September 3, 2014

Fibrin as a Versatile Fibrous Biopolymer.

John W Weisel¹, Rustem I Litvinov²

¹Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. weisel@pennmedicine.upenn.edu.

Sub-Cellular Biochemistry

|January 20, 2026

Summary

This summary is machine-generated.

Fibrin, a key blood clot protein, forms a complex network essential for healing and preventing bleeding. Ongoing research explores its structure, mechanical properties, and role in diseases for better medical applications.

Keywords:

Blood clot Fibrin biomaterials Fibrin formation Fibrin mechanical properties Fibrin polymerization Fibrin properties Fibrin rupture resistance Fibrin sealants Fibrin structure Fibrinogen composition Fibrinolysis Thrombus α-Helical coiled-coil

More Related Videos

Preparation of Biopolymer Aerogels Using Green Solvents

Preparation of Biopolymer Aerogels Using Green Solvents

Published on: July 4, 2016

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface

Published on: April 7, 2017

Related Experiment Videos

Last Updated: Jan 22, 2026

Molecular Entanglement and Electrospinnability of Biopolymers

Molecular Entanglement and Electrospinnability of Biopolymers

Published on: September 3, 2014

Preparation of Biopolymer Aerogels Using Green Solvents

Preparation of Biopolymer Aerogels Using Green Solvents

Published on: July 4, 2016

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface

Published on: April 7, 2017

Area of Science:

Biochemistry
Biophysics
Materials Science

Background:

Fibrin is a vital biopolymer involved in hemostasis, thrombosis, and wound healing.
Its structure, derived from fibrinogen cleavage by thrombin, dictates clot formation and mechanical properties.
Understanding fibrin is crucial for addressing bleeding disorders and thrombotic conditions.

Purpose of the Study:

To elucidate the molecular mechanisms of fibrin formation and its structural organization.
To investigate the relationship between fibrin structure and its mechanical properties, including rupture resistance.
To explore fibrin's role in biological functions, pathological conditions, and its applications in medicine.

Main Methods:

X-ray crystallography of fibrinogen.
Computational reconstructions and biochemical/biophysical studies.
Analysis of fibrin structure-property relationships and fibrinolysis.

Main Results:

Fibrin monomers self-assemble into a complex, three-dimensional network through specific molecular interactions.
Fibrin fiber structure significantly influences the mechanical properties and stability of blood clots.
The fibrinolytic system efficiently degrades fibrin, while fibrin itself serves as a biomaterial.

Conclusions:

Significant insights into fibrin formation and structure have been gained, revealing its role in clot mechanics.
Further research is needed to fully understand the molecular basis of fibrin's mechanical properties and its implications in clinical settings.
Fibrin's versatile properties offer potential for therapeutic applications, such as hemostatic sealants and tissue engineering scaffolds.