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Mobile Chat Messaging for Smoking Relapse Prevention: A Randomized Clinical Trial
Tzu Tsun Luk1,2, Xiaoyu Su2, Vanessa Wong2
1Alice Lee Centre for Nursing Studies, National University of Singapore, Singapore.
JAMA Internal Medicine
|January 20, 2026
Summary
Mobile chat messaging significantly increased smoking abstinence rates by nearly 30% in a randomized trial. This scalable intervention helps individuals maintain cessation after quitting smoking.
Area of Science:
- Public Health
- Digital Health
- Behavioral Science
Background:
- Smoking cessation relapse remains high despite evidence-based treatments.
- Mobile interventions present a promising, yet under-explored, strategy for sustained cessation.
- Developing scalable solutions is crucial for widespread public health impact.
Purpose of the Study:
- To evaluate the efficacy of mobile chat messaging for preventing smoking relapse in recent quitters.
- To assess the impact of a digital intervention on maintaining tobacco abstinence.
Main Methods:
- A randomized clinical trial involving adults who recently quit smoking.
- Intervention group received 3 months of mobile chat support (live counselor and chatbot).
- Control group received generic smoking cessation advice via text messages.
Main Results:
- The mobile chat intervention group showed significantly higher biochemically validated abstinence at 6 months (45.9% vs 35.5%).
- Higher rates of prolonged abstinence and 7-day point prevalence abstinence were observed in the intervention group.
- The intervention group experienced a significantly lower relapse rate compared to the control group.
Conclusions:
- Mobile chat messaging is an effective strategy for smoking relapse prevention.
- This digital approach offers a scalable method to support sustained smoking abstinence.
- The findings support the integration of mobile health interventions in smoking cessation programs.
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