Parental Age and Childhood Allergy Risk
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View abstract on PubMed
Summary
This summary is machine-generated.Children born to older mothers show lower risks for developing food allergies, wheezing, and house dust mite sensitization. Advanced maternal age may offer protection against early childhood allergic diseases.
Area Of Science
- Environmental Health
- Pediatric Allergy
- Reproductive Epidemiology
Background
- Childhood allergic diseases stem from complex gene-environment interactions.
- Advanced parental age is linked to genetic and epigenetic alterations, but its impact on childhood allergy risk is not well understood.
Purpose Of The Study
- To investigate the association between parental age at childbirth and the risk of allergic diseases in early childhood.
Main Methods
- A nationwide, prospective birth cohort study (Japan Environment and Children's Study) included 34,942 mother-child pairs.
- Physician-diagnosed allergic outcomes (food allergy, wheeze, asthma, eczema) and house dust mite (HDM) sensitization were assessed up to age 4.
- Multivariable logistic regression with multiple imputation was used to calculate adjusted odds ratios (ORs).
Main Results
- Children of mothers aged 35-39 (OR, 0.79) and 40+ (OR, 0.59) had lower odds of food allergy at age 1 compared to mothers aged 25-29.
- Children of parents both aged 35+ had lower odds of wheezing at age 4 (OR, 0.89).
- Children of older mothers showed reduced odds of HDM sensitization (e.g., mothers 35-39: OR, 0.68).
Conclusions
- Advanced maternal age was associated with reduced odds of food allergy, wheezing, and HDM sensitization in early childhood.
- These findings suggest a potentially protective effect of advanced maternal age against the development of allergic diseases in children.
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