Related Experiment Video
Updated: Jan 22, 2026
15:06
Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
Published on: January 3, 2016
13.4K
Modeling nonlinear scattering of phospholipid-coated microbubbles in elastic media
Ali Rezaei1, David Fernández Rivas2, Guillaume Lajoinie1
1Physics of Fluids department, TechMed Center, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Ultrasonics
|January 20, 2026
Summary
Tissue viscoelasticity significantly impacts microbubble behavior in ultrasound imaging and drug delivery. Simulations show increased elastic modulus enhances scatter response but minimally affects harmonic scattering, altering subharmonic generation. This research informs microbubble contrast agent strategies.
Area of Science:
- Biomedical Engineering
- Acoustics
- Materials Science
Background:
- Microbubble contrast agents enhance ultrasound imaging and drug delivery.
- Bubble behavior is influenced by surrounding tissue viscoelasticity.
Purpose of the Study:
- Simulate scattered pressure from a microbubble in a viscoelastic medium.
- Investigate the relationship between medium and shell viscoelasticity on bubble dynamics.
- Analyze the influence of driving pressure, bubble radius, and elastic modulus.
Main Methods:
- Modified Rayleigh-Plesset equation for bubble dynamics.
- Kelvin-Voigt model for tissue viscoelasticity.
- Simulation of scattered pressure from a phospholipid-coated microbubble.
Main Results:
- Increased medium elastic modulus raises the frequency of maximum scatter response.
- Radial excursion decreases up to 45% with 200 kPa elastic modulus, while scattered pressure increases by 50%.
- Harmonic scattering changes negligibly (5% increase), but subharmonic generation (TR/T2R ratio) is significantly altered with increasing elastic modulus.
Conclusions:
- Tissue viscoelasticity critically affects microbubble acoustic response, particularly subharmonic generation.
- Findings impact strategies for using microbubble contrast agents in medical applications.
- The study highlights the importance of considering medium properties for microbubble-based therapies.
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