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Updated: May 5, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
[Orthostatic Hypotension in Parkinson's Disease]
1Department of Neurology, School of Medicine, Kanazawa Medical University.
None:
Orthostatic hypotension (OH) is a major problem in patients with Parkinson's disease (PD), necessitating careful management by neurologists. Furthermore, understanding the relationship between OH and other non-motor symptoms provides valuable insight into the pathological progression associated with α-synuclein and the clinical subtypes for PD. This study explains the physiological mechanisms of blood pressure regulation and the pathogenesis and management of OH in PD. It also discusses the relationship between OH and other non-motor symptoms, particularly cognitive decline, including verification of the α-synuclein propagation hypothesis.
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