Developing and testing bolt-on enhanced EQ-5D-5L for assessing Chinese patients with chronic obstructive pulmonary...

Area of Science:

• Health Services Research
• Psychometrics
• Respiratory Medicine

Background:

• The EuroQol five dimensions questionnaire (EQ-5D) is a global standard for health-related quality of life (HRQoL) assessment.
• Its sensitivity in detecting health status changes in chronic obstructive pulmonary disease (COPD) patients is suboptimal.
• Bolt-on items can augment the EQ-5D for disease-specific HRQoL measurement.

Purpose of the Study:

• To identify, develop, and psychometrically test respiratory-related bolt-on items for the EQ-5D.
• To enhance the sensitivity of HRQoL assessment in Chinese COPD patients.
• To provide a reference for developing bolt-on items for other diseases.

Main Methods:

• Content review of COPD instruments and qualitative interviews with patients to identify candidate bolt-on items.
• Quantitative assessment of psychometric properties, including test-retest reliability, construct validity, and known-groups validity.
• Exploratory factor analysis for dimensional structure and regression analysis for explanatory power.

Main Results:

• Development and selection of candidate respiratory-related bolt-on items for the EQ-5D.
• Evaluation of the psychometric properties of these bolt-on items in a Chinese COPD patient cohort.
• Assessment of the items' reliability, validity, and explanatory power.

Conclusions:

• The developed bolt-on items offer a novel approach to enhance HRQoL measurement in COPD patients using the EQ-5D framework.
• This study provides a valuable reference for creating disease-specific bolt-on items for other conditions.
• The findings aim to improve the sensitivity and specificity of HRQoL assessments in clinical practice and research.