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Updated: Jan 22, 2026

Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles
Published on: June 25, 2018
Combining Palladium and Metal Alkoxide Enables Chemoselective Access to Flexible Allyl-Pd Oxa-dipoles for
Xin-Han Yang1, Tian-Ci Jie1, Yan-Ping Lu1
1College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.
Abstract:
To address the long-standing challenge of chemoselectivity in manufacturing flexible π-allyl Pd dipoles containing extended linkers, we report a new palladium/metal alkoxide-based double activation catalysis. This catalytic system enables the successful generation of TMM oxa-1,5-dipoles from homoallylic alcohol derivatives via a conceptually distinct "locking-releasing" mechanism, wherein the shielding effect of a bulky metal alkoxide moiety is likely a key factor in the sequential process. The consequent [5 + 5] cycloaddition with cyclic vinylogous anhydrides provides direct access to valuable ten-membered lactones with a broad range of substituents at the C9-position. Moreover, chemoselectively engendering π-allyl Pd 1,7-dipoles with a fully saturated linker in the related [7 + 5] cycloaddition further demonstrates the viability of the catalytic system, affording various sp3-rich 12-membered lactones.
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