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Sleep firing rate homeostasis is disrupted in mild parkinsonism
Bharadwaj Nandakumar1, Ajay K Verma1, Ying Yu1
1Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Abstract:
Reduction in neuronal firing from wake to sleep, i.e., sleep firing rate homeostasis (sFRH), is essential for restorative sleep. Sleep dysfunction is common in Parkinson's disease (PD), but sFRH has not been investigated. Here, using a within-subject design in the nonhuman primate model of PD, we report that thalamocortical sFRH is disrupted in parkinsonism. These findings can inform therapeutic approaches tailored to normalize sFRH and reestablish restorative sleep in PD.
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