Related Experiment Video

Updated: Jan 22, 2026

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

9.3K

Gemcitabine plus selinexor in selective advanced sarcomas: a phase I of the Spanish group for research on sarcoma

Javier Martin-Broto1,2,3, Antonio Casado4, Gloria Marquina4

  • 1Medical Oncology Department, Fundación Jimenez Diaz University Hospital, Madrid, Spain. jmartin@atbsarc.org.

Nature Communications
|January 20, 2026
PubMed

Insights

This Phase I study found that combining gemcitabine with selinexor is a tolerable treatment for advanced sarcomas, establishing a recommended dose for further trials.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Exportin-1 (XPO-1) is implicated in solid tumor drug resistance and poor prognosis.
  • Selinexor, an XPO-1 inhibitor, demonstrates preclinical and clinical efficacy in sarcomas.

Purpose of the Study:

  • To determine the recommended Phase 2 dose (RP2D) of combination gemcitabine and selinexor in advanced sarcomas.
  • To evaluate the safety, efficacy, and quality of life associated with this combination therapy.

Main Methods:

  • A Phase I, classic 3+3 dose-escalation study.
  • Adult patients with advanced sarcomas received gemcitabine and weekly selinexor over 21-day cycles.
  • Seventeen patients were enrolled to assess dose-limiting toxicities and establish the RP2D.

Main Results:

  • The recommended Phase 2 dose (RP2D) was established at dose-level +2: gemcitabine (1200 mg/m²) and weekly selinexor (60 mg), due to better tolerability.
  • The most frequent adverse events were neutropenia (82.4%) and thrombocytopenia (76.5%).
  • An overall response rate (ORR) of 31.25% and a median overall survival (mOS) of 39.5 months were observed.

Conclusions:

  • Combination gemcitabine and selinexor is a tolerable and potentially effective treatment for advanced sarcomas.
  • A Phase II trial is ongoing to further investigate this combination in specific sarcoma subtypes like leiomyosarcoma and MPNST.

More Related Videos

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

14.9K
Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

931

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.2K
Phase Diagrams02:39

Phase Diagrams

A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
49.0K
Phase Transitions02:31

Phase Transitions

Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
22.7K
What is Natural Selection?01:32

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
126.0K
Inductance: Single-Phase And Three-Phase Line01:28

Inductance: Single-Phase And Three-Phase Line

Understanding the inductance of transmission lines is crucial for efficient design and operation in electrical power systems. This discussion delves into the inductance characteristics of single-phase two-wire and three-phase three-wire transmission lines with equal phase spacing.
Single-Phase Two-Wire Line:
A single-phase line consists of two solid cylindrical conductors, denoted as x and y. Each conductor carries phasor currents ix and iy, respectively. Given that the sum of these currents is...
614
Capacitance: Single-Phase And Three-Phase Line01:25

Capacitance: Single-Phase And Three-Phase Line

In electrical power systems, understanding the capacitance of transmission lines is fundamental for efficient operation.
Single-Phase Lines
Consider a single-phase, two-wire transmission line with equal phase spacing energized by a voltage source. One conductor carries a uniform positive charge, while the other carries an equal negative charge. The capacitance C of the line can be derived from the voltage V between the conductors. For a one-meter section of the line, the capacitance is given...
583