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Adapting the ADAPTE framework for Traditional Chinese Medicine clinical practice guidelines: a methodological study.

Xiuli Xie1,2,3, Yangyang Wang1, Heba Hussein4

  • 1Research Group of Standardization of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China.

Chinese Medicine
|January 20, 2026
PubMed
Summary

A new framework, ADAPTE-TCM, was developed to adapt Traditional Chinese Medicine (TCM) clinical practice guidelines. This adaptation ensures methodological rigor for TCM, respecting its unique principles.

Keywords:
ADAPTEAdaptationAdjust and expandGuidelines

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Area of Science:

  • Integrative Medicine
  • Evidence-Based Practice
  • Healthcare Adaptation Methodologies

Background:

  • Standardizing healthcare requires adapting clinical practice guidelines (CPGs).
  • Existing adaptation frameworks, like ADAPTE, are not tailored for Traditional Chinese Medicine (TCM) due to fundamental differences in medical principles.
  • This incompatibility hinders the development of standardized TCM care.

Purpose of the Study:

  • To modify the ADAPTE process for the specific needs of Traditional Chinese Medicine (TCM).
  • To develop a rigorous and culturally sensitive framework for adapting TCM clinical practice guidelines (TCM CPGs).
  • To bridge the gap in existing methodologies for TCM CPG adaptation.

Main Methods:

  • A dual-tiered working group (core team and expert panel) simulated the original ADAPTE process on TCM CPGs.
  • Identified challenges related to TCM diagnostic frameworks and holistic treatment paradigms.
  • Revised the ADAPTE process based on expert evaluation and consensus, resulting in the ADAPTE-TCM framework with 20 modified steps and TCM-specific criteria.

Main Results:

  • The initial ADAPTE-TCM framework was developed through simulated testing and expert feedback.
  • High consensus was achieved among 21 experts evaluating the initial ADAPTE-TCM version.
  • Significant modifications were made to 20 steps, incorporating TCM-specific evaluation criteria and tools.

Conclusions:

  • The ADAPTE-TCM framework offers a methodologically rigorous approach for adapting TCM CPGs.
  • This adaptation enhances the standardization of TCM care while respecting its unique medical traditions.
  • The developed framework serves as a model for evolving evidence-based methodologies to accommodate diverse medical systems.