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Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
Published on: June 23, 2013
A case report of venous air embolism induced by bone marrow cavity irrigation
Boe Feng1, Hong Duan1, Kai Liu2
1Department of Anesthesiology, Kunming Children's Hospital & Children's Hospital of Kunming Medical University, Kunming, China.
Abstract:
Venous air embolism (VAE) is a rare but severe complication that can occur during surgical procedures that involve the exposure of vascular structures or pressurized irrigation. We present a rare instance of severe VAE in a child that transpired during the irrigation of the bone marrow cavity during surgery for femoral osteomyelitis in a 3-year-old girl. The patient experienced a rapid clinical deterioration shortly after the commencement of irrigation with diluted povidone-iodine and saline. This deterioration was characterized by a sudden decrease in end-tidal carbon dioxide, oxygen saturation, pulse rate, and blood pressure. A bedside echocardiogram promptly confirmed the presence of intravascular air bubbles. Rapid symptom relief was achieved through prompt emergency interventions, which included catheter aspiration, 100% oxygen, left lateral positioning, and irrigation cessation. The patient underwent a full recovery without any neurological sequelae. In pediatric orthopedic surgery, the significance of vigilance, immediate echocardiographic assessment, and timely treatment to prevent morbidity and mortality due to VAE is underscored by this case.
Insights
Severe venous air embolism (VAE) occurred during pediatric bone marrow irrigation. Prompt intervention including catheter aspiration and oxygen therapy led to full recovery, highlighting the need for vigilance in orthopedic surgery.
Area of Science:
- Pediatric Orthopedic Surgery
- Anesthesiology
- Critical Care Medicine
Background:
- Venous air embolism (VAE) is a rare yet life-threatening complication during surgical procedures involving vascular structures or pressurized irrigation.
- Pediatric patients undergoing orthopedic surgery are susceptible to VAE, particularly during procedures like bone marrow cavity irrigation.
Purpose of the Study:
- To report a rare case of severe VAE in a pediatric patient during femoral osteomyelitis surgery.
- To emphasize the importance of prompt diagnosis and management of VAE in pediatric orthopedic procedures.
Main Methods:
- A 3-year-old girl with femoral osteomyelitis underwent surgery involving bone marrow cavity irrigation.
- The patient developed rapid clinical deterioration indicative of VAE.
- Diagnosis was confirmed via bedside echocardiogram, and emergency interventions were initiated.
Main Results:
- The patient experienced sudden drops in end-tidal carbon dioxide, oxygen saturation, pulse rate, and blood pressure.
- Interventions including catheter aspiration, 100% oxygen, left lateral positioning, and cessation of irrigation rapidly resolved symptoms.
- The patient recovered fully without neurological deficits.
Conclusions:
- This case underscores the critical need for heightened vigilance during pediatric orthopedic procedures involving potential air introduction.
- Immediate echocardiographic assessment is crucial for rapid VAE diagnosis.
- Timely and appropriate emergency interventions are vital to prevent morbidity and mortality associated with VAE in children.
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