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Effects of Multiple Metaphyseal Hole Creation on Long Bone Growth in a Rabbit Model
Won Myung Kim1, Kyeong Hyeon Park2, Kyoung Mi Lee1,3
1Department of Orthopedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Medical Journal
|January 21, 2026
Summary
Creating a single hole in the bone metaphysis caused overgrowth in rabbits, while two holes led to growth suppression. This suggests vascular disruption influences bone growth regulation.
Area of Science:
- Orthopedics
- Pediatric Orthopedics
- Skeletal Biology
Background:
- Long bone overgrowth is common after pediatric skeletal injury, but growth suppression without direct physeal injury is rare.
- Understanding mechanisms of bone growth regulation is crucial for pediatric skeletal health.
Purpose of the Study:
- To investigate the impact of creating metaphyseal holes on bone growth in a rabbit model.
- To elucidate the underlying mechanisms of bone growth modulation by metaphyseal interventions.
Main Methods:
- Immature rabbits underwent surgical creation of single or dual metaphyseal holes in the tibia.
- Radiographic measurements assessed tibial length changes; histologic analysis and CD31 immunofluorescence evaluated bone formation and angiogenesis.
Main Results:
- A single metaphyseal hole resulted in significant tibial overgrowth compared to controls.
- Dual metaphyseal holes led to significant tibial growth suppression.
- Histology showed increased new bone with one hole and decreased bone formation with two holes, alongside reduced angiogenesis in the two-hole group.
Conclusions:
- A single metaphyseal hole can promote bone overgrowth, while additional holes can suppress growth.
- Vascular disruption is a likely mechanism underlying growth suppression after metaphyseal hole creation.
- These findings offer insights into controlling bone growth and its mechanisms in pediatric cases.
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