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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

520
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

320
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
320
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Updated: Jan 22, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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Genotype-Driven Prognostication in Dilated Cardiomyopathy.

David Hong1, Young-Gon Kim2, Seung Hyeok Bang1

  • 1Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Korean Circulation Journal
|January 21, 2026
PubMed
Summary
This summary is machine-generated.

Genetic testing in dilated cardiomyopathy (DCM) identifies patients with a higher risk of adverse cardiac events. Genotype-positive DCM patients face significantly worse outcomes, highlighting genetic testing

Keywords:
Dilated cardiomyopathyGeneticsHeart failurePrognosis

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Area of Science:

  • Cardiology
  • Genetics
  • Genomics

Background:

  • Dilated cardiomyopathy (DCM) is associated with variable and often poor prognosis.
  • Genetic factors significantly influence DCM development and progression.
  • Identifying high-risk DCM patients is crucial for timely intervention.

Purpose of the Study:

  • To evaluate the prognostic impact of genetic testing in patients diagnosed with DCM.
  • To determine if genetic variants correlate with adverse cardiac outcomes in DCM patients.

Main Methods:

  • Retrospective analysis of 239 DCM patients undergoing genetic sequencing (2018-2023).
  • Patients classified as genotype-positive (pathogenic/likely pathogenic variants) or genotype-negative.
  • Primary outcome: composite of cardiac death, heart transplant, or LVAD implantation at 5 years.

Main Results:

  • Genotype-positive DCM patients (33.1%) showed a significantly higher risk of the primary outcome (HR 1.80, p=0.020).
  • A stepwise increase in adverse events was observed from no variant to VUS to genotype-positive groups (p=0.032).
  • Outcomes varied significantly among genotype-positive patients based on affected functional gene groups (p=0.003).

Conclusions:

  • DCM prognosis is significantly influenced by genetic status.
  • Genetic testing can aid in stratifying DCM patient risk.
  • Further research is needed to optimize clinical application of genetic testing in DCM.