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Updated: Jan 22, 2026

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
Electrospun Nanofibrous Scaffolds for Peripheral Nerve Regeneration: From Biomaterial Design to Multimodal
Bingjie Han1, Jinna Ke1, Ziao Tao1
1Department of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Abstract:
Electrospinning technology has shown great potential in the field of peripheral nerve injury repair due to its biomimetic fiber structure, controllable degradability, and multi-functional loading capacity. This article reviews the application of electrospinning technology in nerve repair, with a focus on discussing its research progress in material modification, scaffold design and construction, and multi-technology collaborative repair. Electrospinning scaffolds can optimize the biocompatibility, cell adhesion, and mechanical properties of nerve conduits through physical and chemical modifications, or through the design and construction of scaffolds. At the same time, by combining technologies such as electrical stimulation, drug-loaded sustained-release, hydrogel filling, and 3D printing, a multi-functional synergistic effect can be achieved. It demonstrates significant advantages in structural design, biological activity regulation, and functional regeneration, accelerating the repair and regeneration of nerves after injury. However, it also faces challenges such as preparation efficiency and clinical transformation verification. The future development direction focuses on achieving precise regulation of neural regeneration and functional recovery.
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