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Late-Onset Bilateral Malignant Ciliary Body Medulloepithelioma in an Adult
Yuto Kaimi1, Shigenobu Suzuki2, Toshihide Ueno3
1Departments of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
Abstract:
We report the first case of bilateral malignant ciliary body medulloepithelioma (CBME) in an adult, with comprehensive histopathological and genomic analyses. The right eye harbored a malignant teratoid CBME with sarcomatous elements, while the left eye showed a non-teratoid variant. Whole-exome sequencing revealed shared chromosomal losses and additional aberrations in the teratoid tumor. No pathogenic germline mutations were identified. These findings suggest a potential correlation between histological subtype and genomic complexity in CBME.
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