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Updated: Jan 22, 2026

Microfluidics in Assessing Platelet Function
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Platelet function abnormalities in acquired hemophilia A.

Raffaella Rossio1, Anna Lecchi1, Silvia La Marca1

  • 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.

Research and Practice in Thrombosis and Haemostasis
|January 21, 2026
PubMed
Summary

Acquired hemophilia A (AHA) patients often have abnormal platelet function, contributing to bleeding. Treatment leading to remission improved platelet function, suggesting a link between platelet function and bleeding severity in AHA.

Keywords:
acquired hemophilia Ableedingfactor VIII inhibitormonoclonal gammopathy of undetermined significanceplatelet function disorder

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Area of Science:

  • Hematology
  • Internal Medicine
  • Clinical Research

Background:

  • Acquired hemophilia A (AHA) presents with distinct bleeding patterns, including soft tissue hematomas and mucocutaneous bleeding, unlike inherited hemophilia.
  • Platelet function disorders can be acquired, often linked to medications, medical conditions, or autoimmune disorders.

Purpose of the Study:

  • To investigate platelet function in patients diagnosed with acquired hemophilia A (AHA) caused by autoantibodies against coagulation factor VIII.
  • To assess the relationship between platelet function abnormalities and bleeding tendencies in AHA patients.

Main Methods:

  • Platelet function was assessed in platelet-rich plasma using established recommendations from the International Society on Thrombosis and Haemostasis.
  • Intraplatelet levels of adenine nucleotides (ADP, ATP), serotonin, and β-thromboglobulin were measured, along with plasma markers of platelet activation (CD40L, soluble P-selectin).

Main Results:

  • All 11 AHA patients exhibited reduced platelet aggregation and secretion.
  • Four patients with monoclonal gammopathy showed impaired aggregation and abnormal platelet granule content, suggesting co-existing delta storage pool disease.
  • Intraplatelet ADP and serotonin levels improved following remission of AHA.

Conclusions:

  • Acquired platelet function abnormalities are common in patients with AHA.
  • These platelet defects may contribute to the significant bleeding tendency observed in AHA.
  • Improving AHA remission correlates with enhanced platelet function.