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Updated: Jan 22, 2026

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
Published on: September 2, 2022
Hydrogen-bond-driven stabilization and antioxidant synergy in Pickering emulsions stabilized by natural
Lu Yin1, Kangjia Han1, Yuxiu Lv1
1Key Laboratory of National Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming, Yunnan 650224, PR China.
Abstract:
To meet the increasing demand for green and sustainable delivery systems in food, cosmetics, and pharmaceuticals and address the research gap in natural polyphenol-cellulose nanocrystal (CNC) composite stabilizers, this study developed a bio-based Pickering emulsion stabilizer via hydrogen bonding between 6'-O-caffeoylarbutin (CA) and CNCs. Results demonstrated CA/CNCs self-assembled into a dense interfacial layer, endowing the emulsion with exceptional stability that was reflected in over 85% curcumin enscapsulation efficiency after 30 days of dark storage and structural integrity at up to 80 °C, while CA-curcumin synergism enhanced antioxidant activity with 76.9% DPPH and 81.2% ABTS+ free radical scavenging rates. FT-IR, 1H NMR, and computational simulations confirmed the hydrogen-bond network between CA and cellobiose as the core stabilization mechanism. This study provides a novel, eco-friendly strategy for high-performance natural stabilizers, offering the advancement of green, functional delivery systems across relevant industries.
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