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Updated: Jan 22, 2026
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
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Research progress in precision medicine for type 2 diabetes based on the GLP-1
Sangui Wang1,2, Chenrong Yuan3, Haifeng Wang1
1Department of Surgery, Dongguan Nancheng Hospital, Dongguan, China.
Frontiers in Endocrinology
|January 21, 2026
Summary
Type 2 Diabetes Mellitus (T2DM) is a growing global health threat. This review covers new treatments like glucagon-like peptide-1 (GLP-1) therapies and metabolic surgery for T2DM management.
Area of Science:
- Endocrinology and Metabolism
- Gastroenterology
- Surgical Innovation
Background:
- Type 2 Diabetes Mellitus (T2DM) affects 9% of the global population, with rising prevalence and younger onset.
- T2DM is a complex metabolic disorder involving insulin resistance and pancreatic beta-cell dysfunction, linked to obesity and cardiovascular disease.
- Current T2DM management strategies are evolving, with significant advancements in therapeutic targets.
Purpose of the Study:
- To comprehensively review current trends in T2DM treatment.
- To explore the molecular profile and biological characteristics of GLP-1 and L-cells.
- To examine the development of GLP-1-related pharmaceuticals and advances in metabolic surgery for T2DM.
Main Methods:
- Literature search of PubMed, Embase, and SciELO databases up to June 2025.
- Inclusion of basic/mechanistic studies, observational studies, and clinical trials.
- Keywords included "diabetes", "type 2 diabetes mellitus", "glucagon-like peptide-1", "L-cell", "metabolic surgery", and "GLP-1 receptor agonists".
Main Results:
- Glucagon-like peptide-1 (GLP-1) based therapies are now a cornerstone in T2DM management.
- Metabolic surgery shows significant potential in ameliorating T2DM symptoms.
- The review synthesizes data on GLP-1 biology, pharmaceutical development, and surgical interventions.
Conclusions:
- GLP-1 therapies and metabolic surgery represent key advancements in T2DM treatment.
- Understanding L-cell biology and GLP-1 pathways is crucial for developing novel therapeutics.
- Future personalized precision medicine strategies for T2DM can benefit from these insights.
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