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Updated: Jan 22, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

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Relationship between body roundness index and mortality rates and life expectancy in populations with metabolic

Xicheng Wang1, Taisheng Wu1, Yan Hong1

  • 1Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng, Henan, China.

Frontiers in Cardiovascular Medicine
|January 21, 2026
PubMed

Insights

Body Roundness Index (BRI) shows a U-shaped link to mortality in Metabolic Syndrome (MetS) patients. Optimal BRI may improve survival, with risks increasing at higher levels, especially for males.

Area of Science:

  • Anthropometry
  • Public Health
  • Epidemiology

Background:

  • Cardiovascular Disease (CVD) is a major health issue.
  • Metabolic Syndrome (MetS) significantly increases CVD risk.
  • The association between Body Roundness Index (BRI) and mortality in MetS is unclear.

Purpose of the Study:

  • To investigate the relationship between BRI and mortality risk in MetS patients.
  • To examine nonlinear associations and potential threshold effects of BRI on mortality.
  • To assess BRI's predictive performance compared to BMI.

Main Methods:

  • Longitudinal analysis of NHANES data (1999-2018) from 19,535 MetS participants.
  • Cox proportional hazards regression and smooth curve fitting to analyze BRI-mortality association.
  • Life table analysis to determine life expectancy by BRI levels.

Main Results:

  • A U-shaped association between BRI and all-cause/cardiovascular mortality was observed (P<0.001).
  • Higher BRI quintiles (Q5) showed increased mortality risk (HR: 1.29 for all-cause, HR: 1.39 for CVD).
  • BRI's predictive performance for all-cause mortality was similar to BMI (AUC: 0.810 vs. 0.802).
  • Significant gender differences were found: males in Q5 had higher risk, while females in Q4 showed a protective effect.

Conclusions:

  • BRI exhibits a U-shaped association with mortality in MetS individuals.
  • BRI demonstrates comparable predictive ability to BMI for all-cause mortality.
  • Maintaining an optimal BRI level may be crucial for improved survival in MetS patients.
Abstract

Keywords:
all-cause mortalitybody roundness indexcardiovascular mortalitylife expectancymetabolic syndrome

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