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Hypertriglyceridemic waist and subclinical atherosclerosis: a systematic review and meta-analysis

Wei Xiong1, Hua Fan2, Yao You3,4,5,6

  • 1Department of Science and Education, The First People's Hospital of Jiande, Hangzhou, China.

Frontiers in Cardiovascular Medicine
|January 21, 2026
PubMed

Insights

Hypertriglyceridemic waist (HTGW) is a cost-effective indicator for detecting subclinical atherosclerosis. This non-invasive test can help identify individuals at risk for cardiovascular events, enabling earlier intervention.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Syndrome
  • Diagnostic Testing

Background:

  • Atherosclerosis is a chronic inflammatory disease leading to cardiovascular events.
  • Subclinical atherosclerosis precedes symptomatic disease.
  • Hypertriglyceridemic waist (HTGW) is a proposed inexpensive, non-invasive marker.

Purpose of the Study:

  • To evaluate the Hypertriglyceridemic waist (HTGW) phenotype as a screening tool for subclinical atherosclerosis.

Main Methods:

  • Systematic literature search across seven databases.
  • Meta-analysis of six studies assessing HTGW and subclinical atherosclerosis.
  • Carotid intima-media thickness and plaque used as surrogate markers.

Main Results:

  • Six studies met inclusion criteria.
  • HTGW was significantly associated with subclinical atherosclerosis (OR = 2.39, 95% CI = 1.63–3.51).

Conclusions:

  • The Hypertriglyceridemic waist (HTGW) phenotype is a viable, inexpensive screening method for subclinical atherosclerosis.
  • This finding supports HTGW as an effective tool for early cardiovascular risk assessment.
Abstract

Keywords:
cardiovascular diseasecarotid intima-Media thicknesshypertriglyceridemic waistmeta-analysissubclinical atherosclerosis

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