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Related Experiment Video

Updated: Jan 22, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
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Electroacupuncture to improve post-stroke cognitive function and modulate cerebral iron deposition: a randomized

Ning Sun1,2, Fang Xie3, Zhe-Tao Wang4

  • 1Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.

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|January 21, 2026
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Electroacupuncture may improve post-stroke cognitive impairment (PSCI) by regulating iron homeostasis. This study investigates electroacupuncture

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Area of Science:

  • Neuroscience
  • Integrative Medicine
  • Medical Imaging

Background:

  • Post-stroke cognitive impairment (PSCI) is a prevalent condition that impedes patient rehabilitation.
  • Iron dysregulation and ferroptosis are implicated in PSCI pathogenesis, yet effective treatments targeting these mechanisms are scarce.
  • Acupuncture's potential to enhance cognition warrants investigation, particularly its early-intervention effects and underlying iron-related mechanisms.

Purpose of the Study:

  • To evaluate the efficacy of electroacupuncture (EA) in improving cognitive function in patients with ischemic stroke-related cognitive impairment (IS-CI).
  • To explore the potential role of cerebral iron deposition, assessed via quantitative susceptibility mapping (QSM), in mediating EA's effects on cognition.
  • To assess the feasibility and preliminary effects of early EA intervention for IS-CI and elucidate iron-related mechanisms.

Main Methods:

  • A single-blind, randomized controlled trial involving 72 IS-CI patients randomized to receive either EA or sham EA (sEA) alongside standard care.
  • Interventions administered 5 times weekly for 4 weeks, with cognitive function assessed using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE).
  • A substudy utilizing 3.0T QSM MRI to quantify regional cerebral iron and correlate changes with cognitive outcomes.

Main Results:

  • Primary outcome: Change in MoCA scores from baseline to week 4.
  • Secondary outcomes: Changes in MMSE, Modified Barthel Index (MBI), Hamilton Anxiety and Depression scales (HAMA, HAMD), Pittsburgh Sleep Quality Index (PSQI), and 3-month PSCI incidence.
  • MRI substudy to investigate the relationship between cerebral iron levels and cognitive improvements.

Conclusions:

  • This trial will provide insights into the effectiveness of EA for IS-CI and its impact on iron homeostasis.
  • Findings may support EA as a therapeutic option for PSCI by targeting iron dysregulation.
  • The study aims to establish a link between EA, cognitive function, and cerebral iron metabolism using advanced imaging techniques.