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Asymmetric Hydrogen Atom Transfer.

Andrew G Feng1, Marcus Vinicius Pinto Pereira Junior2, Scott J Miller2

  • 1Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

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|January 21, 2026
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Summary
This summary is machine-generated.

Asymmetric hydrogen atom transfer (HAT) in radical reactions is now achievable with high enantioselectivity. This perspective reviews recent advances in asymmetric HAT, including H atom donation and abstraction, for synthetic organic chemistry.

Keywords:
asymmetric catalysisbiocatalysishydrogen atom transferphotoredox catalysisradical chemistry

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Area of Science:

  • Synthetic Organic Chemistry
  • Asymmetric Catalysis
  • Radical Reactions

Background:

  • Enantioselective radical reactions are crucial for synthesizing chiral molecules.
  • Hydrogen atom transfer (HAT) is a fundamental process in radical chemistry.
  • Achieving high enantioselectivity in HAT reactions remains a significant challenge.

Purpose of the Study:

  • To provide a comprehensive overview of recent developments in asymmetric hydrogen atom transfer (HAT).
  • To discuss strategies for asymmetric H atom donation (HAD) and H atom abstraction (HAA).
  • To identify future research directions in enantioselective radical reactions.

Main Methods:

  • Review of literature on asymmetric HAT strategies.
  • Categorization of methods based on HAD and HAA.
  • Analysis of established and emergent tactics in enantioselective radical chemistry.

Main Results:

  • Significant progress has been made in asymmetric HAT over the past decade.
  • Successful strategies for both asymmetric HAD to prochiral radicals and HAA from enantiotopic C-H bonds have been developed.
  • A growing number of reports demonstrate high enantioselectivity in HAT reactions.

Conclusions:

  • Asymmetric HAT is a rapidly evolving field with substantial synthetic potential.
  • Continued exploration of novel catalysts and methodologies will further advance enantioselective radical synthesis.
  • This perspective highlights key advancements and future opportunities in asymmetric HAT.