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Updated: Jan 22, 2026
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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
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Optimising multiple myeloma therapy in resource-limited settings: current perspectives and challenges
Bishal Tiwari1,2, Samita Sapkota3
1Nassau University Medical Center, East Meadow, Long Island, NY 11554, USA.
Ecancermedicalscience
|January 21, 2026
Summary
Multiple myeloma (MM) management faces global challenges, especially in resource-limited settings. Improving access to diagnostics and adapting treatments are crucial for better outcomes and reducing health inequities.
Area of Science:
- Hematology
- Oncology
- Global Health
Background:
- Multiple myeloma (MM) incidence and mortality are rising globally.
- Significant disparities exist in MM diagnosis and treatment between high-income countries and low- and middle-income countries (LMICs).
Purpose of the Study:
- To critically review current MM management strategies.
- To highlight disparities in resource-limited settings.
- To propose strategies for improving MM care globally.
Main Methods:
- Comprehensive literature search (2010-2024) across multiple databases.
- Analysis of peer-reviewed articles, clinical guidelines, and conference abstracts.
- Comparative analysis of therapeutic approaches in different income settings.
Main Results:
- High-income countries utilize advanced regimens, stem cell transplantation, and novel maintenance therapies.
- LMICs often rely on less effective, more affordable treatments due to limited access to advanced diagnostics and high-cost therapies.
- Key challenges include late presentation, inadequate infrastructure, economic constraints, and workforce shortages.
Conclusions:
- Enhancing diagnostic capacity is essential.
- Adapting resource-stratified treatment guidelines is necessary.
- Strengthening healthcare systems via policy and collaboration can bridge the care gap and reduce global inequities in MM management.
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