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Updated: Jan 22, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Proton beam therapy as an effective treatment option for recurrent endometrial cancer
Yuta Endo1,2, Yoshiaki Takagawa3,4,5, Yuki Yoshimoto1
1Department of Gynecology, Southern TOHOKU General Hospital, Fukushima, Japan.
Objective:
To evaluate the efficacy and safety of proton beam therapy (PBT) for recurrent endometrial cancer (REC) and to identify predictors of local control (LC).
Methods:
We retrospectively reviewed REC patients treated with PBT at our institution between 2008 and 2021. LC, progression-free survival (PFS), and overall survival (OS) were estimated using the Kaplan-Meier method, and prognostic factors were analyzed. Toxicities were graded according to CTCAE v5.0.
Results:
Nine patients with a total of 14 lesions were included (median follow-up, 36.4 months). The 1- and 2-year LC rates were 80.2 % and 68.8 %, respectively. Median PFS and OS were 13.6 and 36.4 months, respectively. Tumor size significantly influenced LC, with lesions < 22.5 mm showing superior outcomes. No grade ≥ 3 toxicities attributable to PBT were observed.
Conclusions:
These findings suggest that PBT may be a safe and effective salvage treatment for REC, particularly in patients with smaller tumors.
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