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Long-term outcomes of pediatric AML in Tunisia: Lessons from 19 years of practice in Sousse
Donia Bouhoula1, Haifa Regaieg1, Hela Abroug2
1Farhat Hached University Hospital of Sousse, Sousse 4031, Tunisia.
Insights
Pediatric acute myeloid leukemia (AML) treatment in resource-limited areas faces challenges. Idarubicin improved initial remission rates, but overall survival remains low due to relapse and limited transplant access.
Area of Science:
- Pediatric Oncology
- Hematology
- Global Health
Background:
- Pediatric acute myeloid leukemia (AML) treatment presents unique challenges in resource-limited settings.
- Long-term data from such centers are crucial for understanding treatment outcomes and identifying areas for improvement.
Abstract:
Treating pediatric acute myeloid leukemia in resource-limited settings presents unique therapeutic challenges. This study shares 19 years of experience from a Tunisian center, focusing on practical treatment outcomes. Our pediatric AML cohort (n=68) shows 50% initial remission rates (75% with idarubicin vs 31% novantrone) and 9% induction mortality. Despite salvage therapy (43% CR2), 5-year survival remained at 33%, constrained by high relapse (53%) and limited transplant access (21%). These results highlight critical needs: optimized frontline therapy and expanded salvage options for refractory cases.
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