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Pediatric AML in Sousse, Tunisia: Epidemiologic patterns and hierarchical prognostic factors
Donia Bouhoula1, Haifa Regaieg1, Hela Abroug1
1Farhat Hached University Hospital of Sousse, Tunisia.
Insights
Outcomes for pediatric acute myeloid leukemia (AML) in Tunisia show older patients and a high AML2 subtype prevalence. Risk stratification is key for treatment success, highlighting the need for adapted diagnostic protocols in resource-limited settings.
Area of Science:
- Hematology
- Pediatric Oncology
- Epidemiology
Background:
- Outcomes for pediatric acute myeloid leukemia (AML) in resource-limited regions are understudied.
- Understanding regional epidemiologic patterns is crucial for prognostic determinants.
Abstract:
Pediatric acute myeloid leukemia outcomes in resource-limited regions remain understudied, particularly regarding how regional epidemiologic patterns interact with prognostic determinants. Our Tunisian cohort (n=68) reveals distinct pediatric AML features: older presentation (median 11 years), male predominance (63%), and unexpected AML2 subtype prevalence (35%). Cytogenetics showed 24% favorable-risk and 22% adverse-risk cases. Treatment outcomes correlated strongly with risk stratification, emphasizing the need for adapted diagnostic protocols in resource-conscious settings to optimize care pathways.
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