The impact of social vulnerability on primary vaccine coverage in children with sickle cell disease
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View abstract on PubMed
Summary
This summary is machine-generated.Social vulnerability impacts vaccine coverage in children with sickle cell disease (SCD). Targeted outreach in high-vulnerability areas can improve up-to-date (UTD) vaccination rates for essential pediatric vaccines.
Area Of Science
- Pediatric Health
- Public Health
- Immunology
Background
- Children with sickle cell disease (SCD) require timely vaccinations for optimal health outcomes.
- Social vulnerability is increasingly recognized as a barrier to healthcare access and adherence, including immunization.
- Understanding the interplay between social vulnerability and vaccine coverage in pediatric SCD populations is crucial for public health interventions.
Purpose Of The Study
- To examine the association between social vulnerability and up-to-date (UTD) primary vaccine coverage among children with SCD.
- To identify specific social vulnerability factors that influence vaccine completion rates in this population.
Main Methods
- Retrospective cohort study of 1,337 children with SCD born in Georgia (2008-2019).
- Immunization data from state registry linked to Social Vulnerability Index (SVI) scores based on birth address.
- Multivariable logistic regression analysis to assess the relationship between SVI scores and vaccine completion by 24 months.
Main Results
- 58% of children with SCD achieved UTD primary vaccine series by 24 months.
- 37% resided in areas with high SVI.
- Socioeconomic vulnerability was associated with higher odds of UTD coverage for poliovirus, MMR, Hib, and Hepatitis B vaccines.
Conclusions
- Children with SCD are disproportionately affected by social vulnerability, impacting their vaccination status.
- The Social Vulnerability Index can guide targeted vaccine outreach strategies, particularly in areas with high housing and transportation vulnerability.
- Prioritizing multi-dose and varicella vaccines may be beneficial in vulnerable populations.
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