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Published on: August 25, 2016
Nitrogen-rich hyper-cross-linked polymers for rapid and selective bilirubin removal in hemoperfusion
Hongxiang Yin1,2, Yueyuan Xiao1,2, Yucheng Cai1,2
1Key Laboratory of Green Preparation and Application for Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan, 430062, China. willieyan2003@hubu.edu.cn.
None:
Liver failure causes the accumulation of endogenous toxins in the blood; their efficient removal is crucial to support hepatic recovery. Hemoperfusion is an effective detoxification modality but remains limited by the performance of adsorbents. Herein, we report a benzotriazole-functionalized hyper-cross-linked polymer (HCP) with excellent performance as a hemoperfusion adsorbent for the removal of bilirubin. The synthesized HCP exhibits outstanding performance for bilirubin capture, delivering a maximum adsorption capacity of 877 mg g-1 and an equilibrium capacity of 195 mg g-1. This work expands the application of HCPs and provides a viable construction strategy for the development of hemoperfusion adsorbents.
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