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Updated: Jan 22, 2026

Techniques to Induce and Quantify Cellular Senescence
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Cellular Senescence in Heart Failure: A Review

Kamil Krauz1, Katarzyna Czarzasta1, Mikołaj Bugajewski1

  • 1Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.

Journal of Cellular Physiology
|January 21, 2026
PubMed

Insights

Cellular senescence contributes to heart failure (HF) development and progression. Targeting senescent cells and related plasma proteins offers potential therapeutic strategies for improving HF outcomes.

Area of Science:

  • Cardiology
  • Gerontology
  • Cell Biology

Background:

  • Heart failure (HF) is a growing global health concern with limited treatment options.
  • Aging is a major risk factor for HF, and cellular senescence is increasingly implicated in its pathogenesis.
  • The precise role of cellular senescence in HF is complex and cell-type dependent.

Purpose of the Study:

  • To review the intricate relationship between cellular senescence and heart failure.
  • To explore the potential of senescent cell markers in plasma as biomarkers and prognostic indicators for HF.
  • To summarize current and emerging senescence-targeting therapeutics for HF.

Main Methods:

  • Comprehensive literature review of studies on cellular senescence and heart failure.
  • Analysis of research on plasma proteins associated with cellular senescence in HF patients.
  • Evaluation of therapeutic strategies targeting cellular senescence in the context of HF.

Main Results:

  • Cellular senescence, a state of irreversible cell cycle arrest, is a significant contributor to HF pathogenesis.
  • Plasma proteins linked to senescence show promise as biomarkers and prognostic factors for HF.
  • Targeting senescent cells presents a potential therapeutic avenue for HF treatment.

Conclusions:

  • Cellular senescence plays a multifaceted role in the development and progression of heart failure.
  • Further research into senescence-associated plasma proteins could refine HF diagnosis and prognosis.
  • Senolytics and other senescence-targeting therapies warrant investigation for HF management.

Keywords:
agingcellular senescenceheart failure

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