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Yu-Chih Shen1, Chien-Chen Hung2

  • 1Department of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Psychiatry and Clinical Psychopharmacology
|January 21, 2026
PubMed
Summary
This summary is machine-generated.

Intranasal esketamine (Spravato®) showed promising results for a patient with treatment-resistant depression (TRD) and a history of poor response to electroconvulsive therapy (ECT). The treatment improved depression scores and resolved suicidal ideation with manageable side effects.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Treatment-resistant depression (TRD) poses a significant clinical challenge.
  • Limited treatment options exist for patients with TRD and structural brain abnormalities.
  • Prior electroconvulsive therapy (ECT) failure can complicate depression management.