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Fatal Suicide Attempt with Upadacitinib (Rinvoq®) in an Adolescent: A Case Report
Silviya Stoykova1,2, Ivo Ivanov1,2, Evgeniya Byrzashka3,4
1Forensic Toxicology Laboratory, Department of Toxicology, Military Medical Academy, 3, "St. Georgi Sofiyski" Str., 1606 Sofia, Bulgaria.
This case report details the first fatal overdose of upadacitinib (a JAK1 inhibitor) in a 13-year-old, highlighting severe cardiovascular and central nervous system effects. It establishes lethal concentration data and emphasizes medication safety.
Area of Science:
- Pharmacology
- Toxicology
- Clinical Medicine
Background:
- Upadacitinib, a selective Janus kinase 1 (JAK1) inhibitor, is widely used for autoimmune diseases.
- While generally safe, fatal intoxications have not been previously documented.
- This study addresses a critical knowledge gap regarding upadacitinib overdose toxicity.
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Types of Reports I: Hands-off Report
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Purpose and Process:
Types of Reports II: Incident or Occurrence Report
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...

