Related Experiment Video

Updated: Jan 22, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

Pharmacological Management of Mild Cognitive Impairment: From Symptomatic Treatment to Disease Modification-A

Andrei Gabriel Mangalagiu1,2, Bogdan Mircea Petrescu1,2, Sorin Riga3

  • 1Discipline of Psychiatry II, Department of Clinical Neurosciences, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Neurosci
|January 21, 2026
PubMed

Insights

Managing mild cognitive impairment (MCI) involves optimizing existing medications and addressing vascular risks. Further research is needed to confirm the efficacy and safety of pharmacological treatments for MCI.

Area of Science:

  • Neurology
  • Pharmacology
  • Geriatrics

Background:

  • Mild cognitive impairment (MCI) has typical annual conversion rates to dementia of 5-15%.
  • MCI requires therapeutic attention due to its progression to dementia.
  • Pharmacological interventions for MCI are under investigation.

Purpose of the Study:

  • To review available data on the efficacy and tolerability of pharmacological treatments for MCI.
  • To identify and categorize various therapeutic interventions for MCI.
  • To suggest a pragmatic pharmacological approach for MCI management.

Main Methods:

  • Conducted a narrative review of studies published over the last 25 years.
  • Searched PubMed/MEDLINE, Cochrane Database of Systematic Reviews, and Web of Science (WoS) Core Collection.
  • Classified retrieved interventions into five categories: cognitive enhancers, disease-modifying, vascular risk mitigation, adjuvant/nootropic, and non-cognitive symptom management.

Main Results:

  • Systematic deprescribing and optimizing concomitant therapies are broadly applicable.
  • Reducing anticholinergic/sedative load, avoiding iatrogenic hypoglycemia, and managing blood pressure are key.
  • Individualized treatment of vascular risk factors is important.
  • Most broadly applicable pharmacological strategies in MCI include systematic deprescribing and optimization of concomitant therapies, reducing anticholinergic and sedative load, avoiding iatrogenic hypoglycemia and excessive blood pressure lowering, and careful, individualized treatment of vascular risk factors.

Conclusions:

  • A pragmatic pharmacological approach to MCI is suggested, based on RCTs, meta-analyses, and guidelines.
  • Further well-designed trials are urgently needed to confirm the efficacy and safety of MCI pharmacological interventions.
  • Optimizing existing medications and managing vascular risk factors are crucial in the current management of MCI.
Keywords:
Ginkgo bilobacholinesterase inhibitorsciticolinedonanemablecanemabmajor neurocognitive disordermemantinemild cognitive impairmentmild neurocognitive disorderracetams

More Related Videos

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.0K
Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.7K

Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
548
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
704
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.0K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
836
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
36.8K
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
1.3K