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Female Aging Affects Coilin Pattern in Mouse Cumulus Cells.

Alexey S Anisimov1, Dmitry S Bogolyubov2, Irina O Bogolyubova2

  • 1Department of Cytology and Histology, Faculty of Biology, Saint Petersburg State University, 199034 St. Petersburg, Russia.

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Summary

Maternal aging reduces coilin-positive nuclear bodies in cumulus cells (CCs), suggesting a potential biomarker for ovarian aging. This change appears linked to cell metabolism, not gene expression.

Keywords:
3D image analysisCajal bodiesbioinformatics analysiscoilincumulus cellsgranulosa cellsimmunocytochemistryovary aging

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Area of Science:

  • Cell Biology
  • Reproductive Biology
  • Aging Research

Background:

  • Cumulus cells (CCs) are crucial for oocyte development and viability.
  • Nuclear bodies (NBs), like Cajal bodies (CBs), reflect nuclear function.
  • Coilin is a key structural protein in CBs.

Purpose of the Study:

  • To investigate maternal aging-associated changes in coilin patterns within mouse CCs.
  • To explore the potential of CCs as a biomarker for ovarian aging.

Main Methods:

  • Fluorescent and electron microscopy were used to examine CCs from mice of different ages.
  • External transcriptome data analysis assessed gene expression of key components (Coil, Smn1).

Main Results:

  • Older mice exhibited a reduced number of coilin-positive NBs in CCs.
  • No significant changes in *Coil* and *Smn1* gene expression were observed with aging.
  • Hypothesized that metabolic changes, not gene expression, drive age-related NB dynamics.

Conclusions:

  • Age-related alterations in coilin-positive NBs in CCs may indicate ovarian functional aging.
  • CCs, readily available from IVF, offer a promising source for aging biomarkers.