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Characterizing Differences in Endolymphatic Hydrops Signatures Among Meniere's Disease Patients with and Without

Yoshiyuki Sasano1,2, Fumihiro Mochizuki2, Yusuke Ito2

  • 1Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Medical Sciences (Basel, Switzerland)
|January 21, 2026
PubMed

Insights

Migraine patients with Meniere's disease show distinct bilateral endolymphatic hydrops patterns on MRI. This suggests migraine may influence hydrops, impacting diagnosis and treatment strategies for inner ear disorders.

Area of Science:

  • Neurology
  • Otolaryngology
  • Radiology

Background:

  • Migraine and Meniere's disease frequently coexist, complicating inner ear imaging and diagnosis.
  • Limited comparative imaging data exists for Meniere's disease patients with and without migraine.
  • Endolymphatic hydrops is a key feature in both conditions, but its presentation in comorbid cases is not well understood.

Purpose of the Study:

  • To compare the patterns of endolymphatic hydrops in Meniere's disease patients with and without comorbid migraine using contrast-enhanced MRI.
  • To investigate potential differences in hydrops distribution and severity between the two groups.

Main Methods:

  • Retrospective analysis of 78 Meniere's disease patients undergoing endolymphatic contrast-enhanced MRI (HYDROPS).
  • Patients were categorized into Meniere's disease only (n=56) and Meniere's disease with migraine (n=22) groups.
  • Degree of endolymphatic hydrops (negative, mild, significant) was assessed in the inner ear, cochlea, and vestibule of both affected and healthy ears.

Main Results:

  • Meniere's disease patients without migraine showed significantly more hydrops in the affected ear compared to the healthy ear.
  • Meniere's disease patients with migraine exhibited no significant interaural differences in hydrops, with higher rates of significant hydrops in the 'healthy' cochlea and inner ear.
  • Bilateral hydrops was significantly more frequent in the Meniere's disease with migraine group across all investigated regions.

Conclusions:

  • Meniere's disease patients with migraine present a unique endolymphatic hydrops pattern characterized by bilateral or symmetrical involvement.
  • Migraine-related mechanisms may contribute to the development of endolymphatic hydrops.
  • Bilateral endolymphatic hydrops on MRI in suspected Meniere's disease warrants consideration of comorbid migraine.
Keywords:
HYDROPSMeniere’s diseaseendolymphatic contrast-enhanced MRIendolymphatic hydropsmigraine

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