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Aspersorbiciols A and B, Two Hybrid Sorbicillinoids with an Undescribed Skeleton from a Marine-Derived Fungus
Quan Teng1, Zhen Li2, Pei Cao1
1Guangxi Key Laboratory of Marine Drugs/Institute of Marine Drugs/University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi University of Chinese Medicine, Nanning 530200, China.
Abstract:
Aspersorbiciols A and B, two hybrid sorbicillinoids, were obtained from marine fungus Aspergillus sp. GXIMD02072. Their structures were elucidated by spectroscopic analyses, quantum chemical calculations, and X-ray diffraction. Structurally, aspersorbiciols A and B represented the first reported instances of sorbicillinoids incorporating a 2,6-dioxa-pentacyclo-[10.4.0.04,8.04,16.08,13]-hexadecane cage-like skeleton. Aspersorbiciols A and B suppressed lipopolysaccharide-induced NF-κB luciferase activities and the receptor activator of NF-κB ligand-induced osteoclastogenesis.
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